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Skip to Search Results- 21Graduate and Postdoctoral Studies (GPS), Faculty of
- 21Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 7Biological Sciences, Department of
- 7Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 3Biochemistry, Department of
- 3Biochemistry, Department of/Journal Articles (Biochemistry)
- 8Department of Chemistry
- 3Faculty of Pharmacy and Pharmaceutical Sciences
- 2Department of Chemical and Materials Engineering
- 2Department of Oncology
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Biochemistry
- 4Vederas, John (Chemistry)
- 2Unsworth, Larry (Chemical and Materials Engineering)
- 1Derda, Ratmir
- 1Dr. Kaur, Kamaljit (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Kaur, Kamaljit (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
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(RADA)4 Self-Assembling Peptide based Hydrogels: Design, Characterization and In-Vitro Biological Evaluation
DownloadFall 2016
Ionic self-assembling peptides have emerged as promising nano-biomaterials, with direct applications in the fields of bioengineering and applicative medicine. (RADA)4 is a self-assembling 16 residue containing peptide, with alternating hydrophobic and hydrophilic residues. This characteristic...
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Design, Synthesis and Evaluation of Cancer Targeting α-Peptides and Novel Peptidomimetic β-Peptides
DownloadFall 2010
Current cancer therapies have low specificity for tumor cells and have serious toxic side effects. Targeting drugs to the cancer cells can help improve the outcome of existing cancer therapies. In recent years, a number of peptides have been identified by peptide phage display for targeting...
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Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses
DownloadFall 2010
The Hepatitis B virus (HBV) chronically infects 350 million individuals worldwide, leading to mortality by end-stage liver disease, liver cirrhosis, and hepatocellular carcinoma. The vaccine to prevent HBV infection is highly effective but is not extensively available in endemic areas, resulting...
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Development and Application of Protected Amino Acids for the Installation of Stable Post-translational Modifications Using Solid-Phase Peptide Synthesis
DownloadFall 2022
This thesis describes the synthesis of non-canonical amino acid building blocks and their use in solid-phase peptide synthesis (SPPS) to explore peptidic drug analogues based on natural products. We replaced sensitive functionalities found in the structure of naturally produced peptides with...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...
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Fall 2013
Protein adsorption at the biomaterial-tissue interface has several detrimental consequences which undermines the widespread application of engineered materials. Herein, it was asked what role protein secondary structures play in the adsorption of peptides, as well as how these structures affect...
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Endogenous hypothalamic somatostatins differentially regulate growth hormone secretion from goldfish pituitary somatotropes in vitro
Download2003
Davis, P.J., Peter, R.E., Chang, J.P., Graves, C., Smith, S., Rivier, J.E., Yunker, W.Y., Unniappan, S.
Using Southern blot analysis of RT-PCR products, mRNA for three different somatostatin (SS) precursors (PSS-I, -II, and -III), which encode for SS14, goldfish brain (gb)SS28, and [Pro2]SS14, respectively, were detected in goldfish hypothalamus. PSS-I and -II mRNA, but not PSS-III mRNA, were also...
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Endogenous melanocortin antagonist in fish: Structure, brain mapping and regulation by fasting of the goldfish agouti-related protein gene
Download2003
Cerdá-Reverter, J.M., Peter, R.E.
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin. In mammals, central AGRP expression is restricted to the arcuate nucleus in which it plays a key role in the control of energy balance by antagonizing melanocortin effects at melanocortin 4 receptors. In goldfish,...
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Fall 2015
Tumor targeting ligands provide a promising solution to the problems associated with the selective delivery of conventional cancer chemotherapeutics and diagnostics to cancer cells. Therefore, numerous cancer cell surface targeting peptides have been identified and evaluated. These peptides have...