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Skip to Search Results- 3Boyd, T. J. M.
- 3Deyholos, Michael K.
- 2Barr, H. C.
- 2Harrington, Michael J.
- 2Hegele, Robert A.
- 2Rankin, Robert
- 63Graduate and Postdoctoral Studies (GPS), Faculty of
- 63Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 9Biological Sciences, Department of
- 6Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 3Biological Sciences, Department of/Other Publications (Biological Sciences)
- 3Physics, Department of
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Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
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Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair
Download2011
Tiong, S., McKim, K.S., Campbell, S.D., White-Brown, S.K., Paul, A., Pedersen, M., Joyce, E.F.
Ataxia telangiectasia–mutated (ATM) and ataxia telangiectasia–related (ATR) kinases are conserved regulators of cellular responses to double strand breaks (DSBs). During meiosis, however, the functions of these kinases in DSB repair and the deoxyribonucleic acid (DNA) damage checkpoint are...
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Drosophila Mage, a component of Smc5/6 DNA response complex, confers resistance to caffeine and genotoxic stress and plays a role in the cell cycle and cell survival
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Over 50 Melanoma-associated antigen (MAGE) genes have been identified in the human genome. They share a conserved 200 amino acid MAGE-homology domain (MHD). In yeast, the only MAGE homolog (Nse3) is a component of the Smc5/6 DNA damage response complex. In humans, MAGE proteins influence cell...
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Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic review
DownloadSpring 2012
Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from...
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Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications
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Age-related macular degeneration (AMD) is considered a heterogeneous group of disorders. Although many genes influence susceptibility to disease, none has shown to be the primary contributor. To identify genetic contributors, distinct AMD phenotypes need to be established. We relied on...
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Spring 2012
Neuropathic pain afflicts 1.5-3% of the general population. It can be initiated by traumatic nerve injuries or diseases such as diabetic or post-herpetic neuropathy. Neuropathic pain is often initiated by abnormal spontaneous activity in sensory neurons and this provokes increased excitability of...
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Estimation of the Evaporation Rate of an Isolated Water Microdroplet Subjected to Infrared Radiative Heating
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A combined numerical-experimental investigation was performed to study the influence of infrared radiation on the evaporation of a single-component droplet in the range between 10 and 50 micrometers, under different environmental conditions of relative humidity and temperature of air. A numerical...
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Spring 2017
Pulses of ecdysone, a steroid hormone, play an integral role during insect development however, how these ecdysone pulses are regulated has been relatively unexplored. I have shown that the presence of nitric oxide (NO) within the larval prothoracic gland (PG), the principal source of larval...
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Fall 2021
Disease resilience is defined as an animal’s ability to maintain a high level of performance in the face of disease challenges caused by multiple pathogens, as is often the case in commercial pig farms. Therefore, disease resilience is anticipated to be critical to the profitability of the pig...
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Spring 2011
Forkhead (Fox) proteins are transcription factors that function in many processes including development, metabolism and cell cycle regulation. This gene family is divided into subfamilies that appear to originate from a common ancestor. I have identified the evolutionary selection pressures...