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Skip to Search Results- 2Prado, Carla M.
- 1Almasud, Alaa A
- 1Baracos, Vickie E.
- 1Bekaii-Saab, Tanios
- 1Cushen, Samantha J.
- 1Daly, Louise
- 20Graduate and Postdoctoral Studies (GPS), Faculty of
- 20Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 5Department of Agricultural, Food, and Nutritional Science
- 4Department of Oncology
- 2Department of Pharmacology
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Computing Science
- 1Department of Foods and Nutrition
- 1Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Baker, Kristi (Oncology, Medical Microbiology and Immunology)
- 1Baracos, Vickie (Oncology & Agricultural, Food, and Nutritional Science)
- 1Baracos, Vickie (Oncology)
- 1Carla M. Prado (Agricultural, Food, and Nutritional Science)
- 1Dr. Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
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Fall 2019
Postpartum weight retention (PPWR) is an important risk factor for long-term obesity. Accurate assessment and understanding of energy expenditure and other metabolic characteristics of postpartum women may improve weight management following childbirth. The overall aims of this research were to...
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Spring 2019
Energy expenditure forms the basis of all dietary recommendations. In patients with cancer, resting energy expenditure (REE) can be impacted by tumor burden, high systemic inflammation, and/or altered body composition. Total energy expenditure (TEE) and physical activity levels (PAL) have been...
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Spring 2016
Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...
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Microtubules and Energy Metabolism: Targets for Standard, Combination, and Novel Therapeutic Interventions and Monitoring of Cancer
DownloadSpring 2016
The challenge of understanding and treating cancer has proven to be exceedingly complex. At this juncture, understanding cancer from the perspective of a breakdown of a complex cooperative system using a biophysical analysis may aid in improved treatments and prevention of this disease. In any...
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Spring 2022
Targeting DNA repair enzymes has attracted much attention in recent years to overcome the therapeutic resistance in cancer therapy. Inhibition of DNA repair enzymes can be used to make cancer cells sensitive to the DNA damaging effect of ionizing radiation or chemotherapy. In addition, the...
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Nanodelivery of Novel Inhibitors of ERCC1/XPF for sensitizing colorectal cancer cell to platinum drugs
DownloadSpring 2023
This project's long-term goal is to increase the efficacy of genotoxic therapeutics through thesensitization of cells to DNA-damaging therapy ahead of the treatment. The focus of this projectwas on the enhancement of platinum-based chemotherapeutics in colorectal cancer usingcolorectal cancer...
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Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: Selumetinib in patients with cholangiocarcinoma
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Ghosh, Sunita, Doyle, L. Austin, Baracos, Vickie E., Prado, Carla M., Sawyer, Michael B., Bekaii-Saab, Tanios, Shrestha, Suraj
background: Cancer cachexia is characterised by skeletal muscle wasting; however, potential for muscle anabolism in patients with advanced cancer is unproven. methods: Quantitative analysis of computed tomography images for loss/gain of muscle in cholangiocarcinoma patients receiving selumetinib...
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Fall 2014
The purpose of this work is to understand properties of skeletal muscle of cancer patients experiencing severe muscle depletion. These studies were done using computed tomography (CT) imaging and patient information (demographics), and collection of muscle biopsies to analyze using flow...
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Fall 2013
Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, wasting of skeletal muscle driven by reduced food intake and abnormal metabolism. Cachexia has a negative impact on quality of life, response to chemotherapy and survival. Cachexia research is undeveloped with...