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Skip to Search Results- 2Prado, Carla M.
- 1Almasud, Alaa A
- 1Baracos, Vickie E.
- 1Bekaii-Saab, Tanios
- 1Cushen, Samantha J.
- 1Daly, Louise
- 20Graduate and Postdoctoral Studies (GPS), Faculty of
- 20Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 5Department of Agricultural, Food, and Nutritional Science
- 4Department of Oncology
- 2Department of Pharmacology
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Computing Science
- 1Department of Foods and Nutrition
- 1Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Baker, Kristi (Oncology, Medical Microbiology and Immunology)
- 1Baracos, Vickie (Oncology & Agricultural, Food, and Nutritional Science)
- 1Baracos, Vickie (Oncology)
- 1Carla M. Prado (Agricultural, Food, and Nutritional Science)
- 1Dr. Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
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Spring 2010
This thesis presents Pathway Informed Analysis (PIA), a classification method for predicting disease states (diagnosis) from metabolic profile measurements that incorporates biological knowledge in the form of metabolic pathways. A metabolic pathway describes a set of chemical reactions that...
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Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later
Download2016-01-20
Ryan, Aoife M., Power, Derek G., Daly, Louise, Cushen, Samantha J., Ní Bhuachalla, Ēadaoin, Prado, Carla M.
An awareness of the importance of nutritional status in hospital settings began more than 40 years ago. Much has been learned since and has altered care. For the past 40 years several large studies have shown that cancer patients are amongst the most malnourished of all patient groups. Recently,...
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Candidate-Pathway Gene Environment Interactions on Colon and Rectal Cancer Risk and Survival: Methodological Frameworks for Interaction in Genetic Association Studies
DownloadFall 2014
Genetic association studies have adopted for a long time a traditional analytic approach that focuses on individual genetic markers, usually single nucleotide polymorphisms (SNPs), in association with disease or phenotype. A standard single-SNP analysis that ignores combined effects of multiple...
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Fall 2021
One third of all deaths in Canada are due to cardiovascular diseases, including heart failure. Cardiovascular diseases have a considerable economic burden, and drastically impact the health and quality of life of Canadians. Heart failure (HF) is a clinical condition where the heart is unable to...
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Does IGFR1 inhibition result in increased muscle mass loss in patients undergoing treatment for pancreatic cancer?
Download2014
Shroff, R., Katz, M. H., Overman, M. J., Khalil, M., Lieffers, J., Varadhachary, G. R., Fogelman, D., Javle, M. , Holmes, H., Prado, C. M.
BackgroundIGF-1 plays a role in the growth of multiple tumor types, including pancreatic cancer. IGF-1 also serves as a growth factor for muscle. The impact of therapeutic targeting of IGF-1 on muscle mass is unknown.MethodsWe evaluated muscle mass at L3 in patients enrolled in a randomized phase...
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Spring 2021
Lifestyle modifications that induce energy deficit, such as diet and physical activity are considered the cornerstone of weight management. The overall purpose of this research was to compare the effects of an acute nutritional intervention comprised of a high-protein (HP) diet replacement versus...
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Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FU
DownloadFall 2012
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil...