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Subject / Keyword
- 20Pharmacokinetics
- 6Hepatocytes
- 4Nonsteroidal anti-inflammatory agents
- 3Enantiomers
- 3Pharmacodynamics
- 2Biodistribution
Item type
Author / Creator / Contributor
- 1Al Lawati, Hanan M
- 1Anwar-Mohamed, Anwar Gamal Abd El-Naser
- 1Binkhathlan, Ziyad
- 1Carr, Robert Arthur.
- 1Corrigan, Brian W.
- 1El Sayed, Dalia
Year
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Departments
- 17Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Cell Biology
- 1Department of Chemistry
- 1Department of Medical Sciences
- 1Department of Pharmaceutical Sciences
- 1Department of Pharmacology
Supervisors
- 1Brocks, Dion R. (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Dr. Andrew Holt
- 1Dr. Brocks, Dion R (Faculty of Pharmacy and Pharmaceutical Sciences
- 1Dr. Dion R. Brocks, Faculty of Pharmacy and Pharmaceutical Sciences
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 1Jamali, Fakhreddin ( Pharmacy and Pharmaceutical Science)
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The effect of oral lipids and lipoproteins on the biodistribution, metabolism and electrocardiographic side-effects of halofantrine
DownloadSpring 2011
In the past, hyperlipidemia (HL) has been shown to affect the pharmacokinetic and pharmacodynamic properties of lipophilic drugs extensively bound to lipoproteins, including halofantrine (HF). The present thesis examined the effect of HL on the biodistribution, metabolism and electrocardiographic...
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The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole
DownloadFall 2010
The influence of hyperlipidemia on the pharmacodynamic and pharmacokinetic aspects of lipophilic drugs was explored. The antiarrhythmic, amiodarone, and the antifungal, (±)-ketoconazole, were used as model drugs. Experimental hyperlipidemia was induced in rat using poloxamer 407 and two sensitive...
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