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Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant species
Download2013
Kommadath, A., Bao, H., Meng, Y., Plastow, G. S., Stothard, P., Sun, X., Arantes, A. S., Guan, L. L.
Background Understanding how species-specific microRNAs (miRNAs) contribute to species-specific phenotypes is a central topic in biology. This study aimed to elucidate the role of ruminant-specific miRNAs in shaping mRNA expression divergence between ruminant and non-ruminant species. ...
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High resolution optical tweezers for single molecule studies of hierarchical folding in the pbuE riboswitch aptamer
DownloadSpring 2010
Riboswitches are gene regulatory elements found in messenger RNA that function by changing structure upon the binding of a ligand to an aptamer domain. Single adenine-binding pbuE riboswitch aptamer RNAs were unfolded and refolded co-transcriptionally using optical tweezers for single molecule...
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Investigation of an enhancer-based regulation of LILRB1 gene and the differential functions of LILRB1 variants in natural killer cells
DownloadFall 2020
Human cytomegalovirus (HCMV) causes severe disease in immunocompromised people such as transplant patients. NK cells are crucial in controlling HCMV whereas HCMV developed multiple strategies to evade NK cell surveillance. HCMV encodes a human MHC-I homolog called UL18 to target an inhibitory...
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Spring 2013
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
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Spring 2010
Development of the vertebrate central nervous system is a complex process that relies on the accurate spatiotemporal distribution of signaling centers during embryogenesis. These signals provide cells with positional information, which is integrated via transcription factors and gene regulatory...