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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Afrand, Mona
- 1Aktary, Zackie M
- 1Al-Saleh, Mohammed Ali
- 1Aldajani, Tareq
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Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells
DownloadFall 2016
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Development and Validation of Semi-automatic Segmentation Technique of Mandibular Condyles from CBCT images
DownloadSpring 2020
Objectives: Mandibular condyle contains an important growth site that contributes to the eventual anteroposterior position of the mandible, and is a crucial component in establishing normal temporomandibular function. To accurately assess the change in the volume and morphology of the mandibular...
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Fall 2013
The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate...
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Development of a three dimensional analysis of buccolingual inclinations in maxillary transverse deficiencies
DownloadFall 2017
Abstract Introduction: The purpose of this thesis was to develop a new 3D transverse analysis that utilizes a 3D Cartesian coordinate system to assess buccolingual inclinations of first molars and canines using a previously described 3D maxillary reference plane. Landmarks used to create this...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of Genetic Medicines for the Treatment and Prevention of Infectious Disease, Cancer, and Aging
DownloadSpring 2022
Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...
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Fall 2010
In many tumors, persistently-active signal transducer and activator of transcription 3 (STAT3) imparts several oncogenic features such as survival, proliferation, angiogenesis, and immune escape. Therefore, STAT3 targeting in cancer and cancer-exposed dendritic cells (DCs) is important for cancer...
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Development, Validation, and Application of a 3D print out of the Nasopharyngeal area from Cone Beam Computed Tomography in Children
DownloadFall 2019
Cone Beam Computed Tomography (CBCT) is increasingly being used in dentistry to explore certain types of craniofacial abnormalities. Sleep-disordered breathing represents a significant burden to individuals and society. Hence, the opportunistic use of CBCT imaging among dentists to screen for...