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Biochemical investigations of two polyketide synthase subclasses – highly reducing/non-reducing pairs, and polyketide synthase non-ribosomal peptide synthetases.
DownloadSpring 2016
Cladosporin is a polyketide metabolite that is biosynthesized by a highly reducing (HR)/non-reducing (NR) polyketide synthase (PKS) pair, wherein they catalyse head-totail condensation of acetyl and malonyl CoA units with subsequent β-keto modification. Cladosporin has recently been reported as a...
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Biosynthetic Studies of Resorcylic Acid Lactones, Hypothemycin, Radicicol, and Dehydrocurvularin
DownloadFall 2013
Fungal polyketides, a vast source for pharmaceutical industries, are biosynthesized by multifunctional iterative polyketide synthases (PKS). The biosynthesis employs complex programming rules, which are currently unresolved. To decode the programming rules, the biosynthesis of three polyketides,...
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Manipulation of Seed Carbon Flow from Cellulose to Lipid and Protein Biosynthesis in Arabidopsis to Accelerate the Characterization of Protein-Related Genes in Canola
DownloadFall 2023
Canola (Brassica napus L.) is the major oilseed crop in Canada. After oil extraction, the protein-rich seed meal (around 40% protein) serves as a nutritious feedstock for animals and the protein fraction has potential for human consumption. However, excess fiber in the seed meal (about 33%) can...