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2008
Background: Bast fibres from the phloem tissues of flax are scientifically interesting and economically useful due in part to a dynamic system of secondary cell wall deposition. To better understand the molecular mechanisms underlying the process of cell wall development in flax, we extracted...
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Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels
Download2005
Background: Studies of the structure-function relationship in proteins for which no 3D structure is available are often based on inspection of multiple sequence alignments. Many functionally important residues of proteins can be identified because they are conserved during evolution. However,...
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Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair
Download2011
Tiong, S., McKim, K.S., Campbell, S.D., White-Brown, S.K., Paul, A., Pedersen, M., Joyce, E.F.
Ataxia telangiectasia–mutated (ATM) and ataxia telangiectasia–related (ATR) kinases are conserved regulators of cellular responses to double strand breaks (DSBs). During meiosis, however, the functions of these kinases in DSB repair and the deoxyribonucleic acid (DNA) damage checkpoint are...
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Endogenous melanocortin antagonist in fish: Structure, brain mapping and regulation by fasting of the goldfish agouti-related protein gene
Download2003
Cerdá-Reverter, J.M., Peter, R.E.
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin. In mammals, central AGRP expression is restricted to the arcuate nucleus in which it plays a key role in the control of energy balance by antagonizing melanocortin effects at melanocortin 4 receptors. In goldfish,...
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Generation of a restriction minus enteropathogenic Escherichia coli E2348/69 strain that is efficiently transformed with large, low copy plasmids
Download2008
Raivio, T.L., Price, N.L., Ward, J.D., Hobson, N.
Background Many microbes possess restriction-modification systems that protect them from parasitic DNA molecules. Unfortunately, the presence of a restriction-modification system in a given microbe also hampers genetic analysis. Although plasmids can be successfully conjugated into the...
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GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation
Download1999
DiMattia, G.E., Hansen, D., Tahbaz, N., Hobman, T.C., Hendricks, L.C., Pilgrim, D., Cikaluk, D.E.
A panel of mAbs was elicited against intracellular membrane fractions from rat pancreas. One of the antibodies reacted with a 95-kDa protein that localizes primarily to the Golgi complex or the endoplasmic reticulum (ER), depending on cell type. The corresponding cDNA was cloned and sequenced and...
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Large-scale proteome profile of the zebrafish (Danio rerio) gill for physiological and biomarker discovery studies
Download2009
De Souza, A. G., Goss, G. G., MacCormack, T. J., Wang, N., Li, L.
Abstract: Zebrafish are an important model in vertebrate genetics, developmental biology, physiology, and toxicology. In this study, we established the first large-scale proteome profile of a teleost fish tissue using a shotgun method based on two-dimensional liquid chromatography-electrospray...
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Modulation of citrate metabolism alters aluminum tolerance in yeast and transgenic canola overexpressing a mitochondrial citrate synthase
Download2003
Basu, U., Anoop, V. M., Taylor, G. J., McAlister-Henn, L., McCammon, M. T.
Aluminum (Al) toxicity is a major constraint for crop production in acid soils, although crop cultivars vary in their tolerance to Al. We have investigated the potential role of citrate in mediating Al tolerance in Al-sensitive yeast (Saccharomyces cerevisiae; MMYO11) and canola (Brassica napus...
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1987
Owttrim, George W., Coleman, John R.
A recA-like gene isolated from the cyanobacterium Anabaena variabilis was cloned and partially characterized. When introduced into Escherichia coli recA mutants, the 7.5-kilobase-pair plasmid-borne DNA insert restored resistance to methyl methanesulfonate and UV irradiation, as well as...