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Skip to Search Results- 14Cytochrome P450
- 10Bark beetles
- 4Coleoptera
- 3Cardiac hypertrophy
- 2Arachidonic Acid
- 2Arachidonic acid
- 6Keeling, Christopher I.
- 3Bohlmann, Joerg
- 2Bohlmann, Jörg
- 2Carroll, Allan L.
- 2Chan, Simon K.
- 2Chiu, Christine C.
- 11The NSERC TRIA Network (TRIA-Net)
- 11The NSERC TRIA Network (TRIA-Net)/Journal Articles (TRIA-Net)
- 8Biological Sciences, Department of
- 8Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 8Graduate and Postdoctoral Studies (GPS), Faculty of
- 8Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Ayman, El-Kadi (Pharmacy and Pharmaceutical Sciences)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 1Jamali, Fakhreddin (Pharmaceutical Sciences)
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Genes, enzymes, and chemicals of terpenoid diversity in the constitutive and induced defence of conifers against insects and pathogens
Download2006-02-02
Keeling, Christopher I., Bohlmann, Jörg
Insects select their hosts, but trees cannot select which herbivores will feed upon them. Thus, as long-lived stationary organisms, conifers must resist the onslaught of varying and multiple attackers over their lifetime. Arguably, the greatest threats to conifers are herbivorous insects and...
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2006
Wang, W., Li, J., Liu, D., Lu, Z., Zheng, H., Wong, G., Cai, Z., Fan, C., Zhang, J., Vang, S., Long, M., Zhang, G., Wang, J., Shi, J.
Retroposition is widely found to play essential roles in origination of new mammalian and other animal genes. However, the scarcity of retrogenes in plants has led to the assumption that plant genomes rarely evolve new gene duplicates by retroposition, despite abundant retrotransposons in plants...
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Fall 2012
Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...
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MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHY
DownloadSpring 2017
El-Sherbeni, Ahmed Abd El-Hakeem
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGET
DownloadSpring 2017
Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...
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Phoretic mite associates of mountain pine beetle at the leading edge of an infestation in northwestern Alberta, Canada
Download2011
Proctor, H. C., Evenden, M. L., Mori, B. A., Walter, D. E.
Abstract: We identified species of mites phoretically associated with mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae: Scolytinae), collected from bolts of lodgepole pine, Pinus contorta Douglas ex Louden (Pinaceae), and pheromone-baited traps in northwestern...
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Phytochemicals as mediators for host range expansion of a native invasive forest insect herbivore.
Download2019-01-01
Mountain pine beetle (MPB, Dendroctonus ponderosae) has recently breached the geo-climatic barrier of the northern Rocky Mountains and invaded novel jack pine (Pinus banksiana) forests in western Canada. This breach signifies an unprecedented climate change-induced invasion of a new plant biome...
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The cytochrome P450 CYP6DE1 catalyzes the conversion of α-pinene into the mountain pine beetle aggregation pheromone trans-verbenol
Download2019-01-01
Chiu, Christine C., Keeling, Christopher I., Bohlmann, Joerg
The recent outbreak of the mountain pine beetle (Dendroctonus ponderosae; MPB) has afected over 20M hectares of pine forests in western North America. During the colonization of host trees, female MPB release the aggregation pheromone (−)-trans-verbenol. (−)-trans-Verbenol is thought to...
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The role of cytochrome P450 and the protective effect of EETs against isoproterenol-induced cellular hypertrophy in rat H9c2 cell line
DownloadSpring 2013
Cytochrome P450 (CYP) enzymes have been identified in the heart and their levels have been reported to be altered during cardiac hypertrophy and heart failure. Furthermore, CYP enzymes have been shown to metabolize arachidonic acid to cardioprotective epoxyeicosatrienoic acids (EETs) and...
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THE ROLE OF CYTOCHROME P450 AND THEIR ASSOCIATED ARACHIDONIC ACID METABOLITES IN THE INITIATION AND PROGRESSION OF CARDIAC HYPERTROPHY
DownloadSpring 2016
Heart failure (HF) is the leading cause of mortality and disability in adults worldwide. Cardiac hypertrophy is an independent risk factor and one of the major hallmarks of HF. Research in cardiac hypertrophy is considered as a research into the early events in the development of HF. The...