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Skip to Search Results- 78Graduate and Postdoctoral Studies (GPS), Faculty of
- 78Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 12School of Public Health
- 11Nursing, Faculty of
- 10School of Public Health/Journal Articles (Public Health)
- 6Biological Sciences, Department of
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Fall 2009
There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...
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Antimicrobial Resistant Campylobacter species in the Food Chain: Understanding the Human Risk of Infection
DownloadFall 2022
Background: Campylobacter spp., commonly detected in poultry, are the third most common cause of foodborne illness in Canada. Campylobacter while self-limiting and typically only requiring supportive care treatment, can be resistant to antimicrobials important to human health. To better...
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Application of ROC curve analysis to metabolomics data sets for the detection of cancer in a mouse model
DownloadFall 2010
The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...
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Spring 2022
Carotid atherosclerosis is responsible for 15-25% of the nearly 8 million first-ever ischemic strokes that occur each year worldwide. This proportion has remained constant over the past three decades, thus suggesting that some patients with carotid atherosclerosis currently receive suboptimal...
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Fall 2018
Background: Cancer-associated venous thromboembolism (VTE) is associated with significant morbidity and mortality. Cancer patients are at higher risk of VTE recurrence despite anticoagulation and bleeding complications while on anticoagulation. There are some risk factors of bleeding specific...
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2008-12-01
Kelly, Janet, Lanier, Anne, Santos, Maria, Healey, Sylvia, Louchini, Rabia, Friborg, Jeppe, Young, T. Kue
"Objectives: This is first of 2 papers on the Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada and Greenland. It covers the period 1989–2003, updating the last review (1969-1988) and together provides an overview...
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2008-12-01
Kelly, Janet, Lanier, Anne, Santos, Maria, Healey, Sylvia, Louchini, Rabia, Friborg, Jeppe, Young, T. Kue
"Objectives: This is the second of 2 papers reporting on the result of the Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada and Greenland. Methods: Inuit cancer cases by age-sex group and anatomic site were...
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Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later
Download2016-01-20
Ryan, Aoife M., Power, Derek G., Daly, Louise, Cushen, Samantha J., Ní Bhuachalla, Ēadaoin, Prado, Carla M.
An awareness of the importance of nutritional status in hospital settings began more than 40 years ago. Much has been learned since and has altered care. For the past 40 years several large studies have shown that cancer patients are amongst the most malnourished of all patient groups. Recently,...