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ENDOTHELIAL CELL HETEROGENEITY: A CORRELATION WITH THE VON WILLEBRAND FACTOR EXPRESSION IN DISTINCT ORGANS
DownloadSpring 2017
Endothelial cells (EC) of different organs exhibit heterogeneity in structure, function and gene expression pattern. This also extends to the pattern in which the highly endothelial-specific gene, von Willebrand Factor (VWF) is expressed. VWF is a multimeric adhesive, pro-coagulant glycoprotein...
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Matrix metalloproteinase‐2, caveolins, focal adhesion kinase and c‐Kit in cells of the mouse myocardium
Download2007-01-01
Cho, Woo Jung, Chow, Ava K., Schulz, Richard, Daniel, Edwin E.
Matrix metalloproteinase‐2 (MMP‐2) may play roles at intracellular and extracellular sites of the heart in ischaemia/reperfusion injury. Caveolins (Cav‐1, ‐2 and ‐3) are lipid raft proteins which play roles in cell sig‐nalling. This study examined, using immunohistochemistry and two photon...
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Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
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The mechanism of endothelial cell specific gene expression of Von Willebrand Factor in vivo
DownloadSpring 2010
In vivo analyses of the Von Willebrand Factor (VWF) promoter previously demonstrated that a fragment spanning sequences -487 to +247 targets promoter activation to brain vascular endothelial cells. This fragment is active in all embryonic vessels of transgenic mice but in adult mice its activity...
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Transcriptional regulation of von Willebrand Factor gene in response to hypoxia and in cancer cells
DownloadFall 2016
Von Willebrand Factor (VWF) is a pro-coagulant, glycosylated protein that is exclusively expressed in endothelial cells and megakaryocytes. An acute phase protein, VWF is upregulated or released from activated or injured endothelial cells. In addition, it is a carrier for factor VIII that...