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Skip to Search Results- 1Beck, Elizabeth M
- 1Choo-Yin, Yemayá Yue
- 1Elezzabi, Muhammad A.
- 1Ellestad, Kristofor K
- 1Havele, Calliopi.
- 1Hu, Qian
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Fall 2014
The oil sands landscape in northern Alberta is interspersed with large tailings ponds that hold wastewater from bitumen mining and extraction processes. Recent monitoring results indicate that annually many thousands of birds, mostly migrating waterfowl, land on the ponds associated with this...
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Mechanisms underlying lymphopenia-driven autoimmunity in the setting of co-inhibitory molecule deficiency
DownloadFall 2016
T lymphocytes (T cells) are powerful directors and effectors of immunity. The system of pseudo-random rearrangements of the T cell receptor (TCR) loci that underlie their ability to recognize a vast universe of molecular patterns is at once useful and dangerous, because many T cells develop TCR...
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Monitoring Macrophage Immune Gene Expression Profiles as an Early Indicator System for Examining the Bioactivity of Oil Sands Process Affected Waters
DownloadFall 2021
Oil sands process-affected waters (OSPW) are by-products of bitumen (i.e. oil) extraction from the oil sands located in northern Alberta. These large volumes of water are held in tailings ponds and cannot be released due to their potential toxic effects. Overall, tailings ponds and mining...
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Fall 2011
The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells occurs in both natural and artificially induced states of lymphopenia. Although lymphopenia leads to homeostatic proliferation of T...
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Fall 2023
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid-derived cardiac metabolite produced in endotoxin-induced cardiomyopathy, correlating with myocardial dysfunction, inflammation, and mitochondrial damage. The contribution of 12,13-DiHOME to inflammation in the heart is...
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T Cell Generation in a Lymphopenic Environment Generates Disease when the Thoracic Thymus is Eliminated; Augmentation by IL-7/Anti-IL-7 Complexes
DownloadSpring 2012
Cervical thymus functionally mimics the thoracic thymus in supporting T cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus generates an overall repertoire of T cells that are self-tolerant similar to the thoracic thymus. Mice...