Search
Skip to Search Results- 1Acedo, Jeella Z
- 1Cochrane, Stephen A.
- 1Fagan-Garcia, Katharine
- 1Griffiths, Cameron
- 1Ho, Linda
- 1Hosseini, Seyedeh Nargess
-
The mechanism of action of cidofovir and (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine against viral polymerases
DownloadFall 2009
The nucleoside phosphonates cidofovir (CDV) and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [(S)-HPMPA] are analogs of dCMP and dAMP, respectively. Collectively these drugs are effective inhibitors of a wide range of DNA viruses, RNA viruses, and retroviruses. Because they are nucleotide...
-
Spring 2010
Although nanocrystalline silver is used commercially to treat burns and wounds, the mechanisms of action (MOA) for its activity are not clear. The purposes of this work were to determine if nanocrystalline silver has anti-inflammatory activity, determine physicochemical properties critical for...
-
A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signaling
DownloadFall 2010
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
-
Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
-
Synthesis and biological evaluation of the lantibiotic peptide lactocin S and its analogues
DownloadSpring 2012
Lantibiotics (lanthionine containing antibiotics) are highly post-translationally modified peptides used by bacteria as a form of chemical warfare. In light of the challenges faced today in the field of antibacterial therapy, these potent natural products are useful lead compounds for the...
-
Application of antimicrobials for the elimination of Escherichia coli and Listeria monocytogenes in brine injected beef
DownloadFall 2013
The application of antimicrobials to a brine-injected raw beef roast for the elimination/inhibition of heat resistant Escherichia coli and Listeria monocytogenes was investigated. The choice of antimicrobials for use in brine injected beef was based on minimum bactericidal concentration in brine...
-
Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
-
Fall 2014
Paenibacillus polymyxa NRRL B-30509, Paenibacillus terrae NRRL B-30644 and P. polymyxa NRRL B-30507 were found to produce several bacteriocins and non-ribosomal peptides. All three strains produce tridecaptins, non-ribosomal lipopeptides antimicrobially active against food pathogen Campylobacter...
-
Fall 2016
“Blown-pack” spoilage of beef by psychrotrophic Clostridium spp. occurs sporadically and resistance of the endospores to most interventions makes them very difficult to control. Current interventions used to control spoilage and pathogenic bacteria, such as acid washes and heat treatments, do...