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Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
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Fall 2017
Most antivirals target viral proteins and are specific for only one virus, or even one viral genotype. Whereas viral proteins are encoded in the plastic viral genome, virion lipids are not and their rearrangements during fusion of the virion envelope to cellular membranes are conserved among...
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Characterizing the effects of differentially adapted influenza PB2 proteins on duck MAVS-mediated interferon beta signaling
DownloadFall 2015
The influenza A viral RNA polymerase is responsible for viral replication and greatly affects influenza A virus (IAV) virulence and host range. The PB2 influenza polymerase subunit is the primary polymerase determinant of influenza host range and virulence. It was previously shown that PB2...
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Development of Oral Influenza Vaccine Delivery System Utilizing pH Responsive Pored Microparticles
DownloadFall 2015
Influenza is a major respiratory disease caused by influenza virus. Recent spread of the extremely pathogenic avian and swine influenza viruses paint a morbid picture of the emergence of a more lethal influenza virus in future. Currently, hypodermic needles are being dominantly employed in...
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Diabetes and Influenza-Attributable Illness: The Rationale for Targeted Influenza Vaccinations in Adults with Diabetes
DownloadFall 2012
While guidelines for seasonal influenza vaccinations single out working age (< 65) adults with diabetes, vaccination rates in this group remain below national targets. Historically, there has been limited evidence to support these guidelines. This dissertation comprises four studies investigating...
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Spring 2013
Immunogenicity of intramuscular influenza vaccine is suboptimal in organ transplant recipients although intradermal vaccine may be superior by targeting dermal dendritic cells to stimulate a response. 229 patients were randomized to IM or high-dose ID vaccine during the 2010-11 season. Pre- and...
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Inhibition and enhancement of Respiratory Syncytial Virus replication by nucleoside analogues and bis(indole) compounds
DownloadSpring 2019
Respiratory syncytial virus (RSV) is an Orthopneumovirus that infects the epithelium of the airways. Severe RSV infection of the lower respiratory tract in infants is a leading cause of pediatric hospitalizations. RSV also causes substantial morbidity in immunocompromised and elderly populations....
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Spring 2010
These two studies investigate the immune responses of lung and kidney transplant recipients to the influenza vaccine. The study involving kidney transplant recipients developed a novel flow cytometry assay to measure cell-mediated immunity in response to influenza vaccination. The activation of...
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2007
Lake, R., Bailey, T., Yonge, O., Marrie, T.J., Herman, B., Rosychuk, R.J.
To assess knowledge of pandemic influenza, we administered a questionnaire to all medical students at the University of Alberta; 354 (69%) of 510 students responded. Data from questionnaires such as this could help determine the role of medical students during a public health emergency.