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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Akinwumi, Segun M
- 1Anderson, Sarah J
- 1Badejo, Ifueko
- 1Badr, Dina EFA
- 1Beltaos, Angela M
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Fall 2017
Since European settlement of the Canadian Prairies there has been substantial loss of wetlands. This loss occurs in large part due to drainage by private agricultural operators seeking to boost the productivity of their land. Policy makers now seek not only to conserve wetlands and prevent...
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Fall 2020
Introduction: ABO-incompatible organ transplants (ABOi-Tx) recipients are at high-risk of rapid rejection mediated by ABO antibodies (ABO Abs). To manage and expand ABOi-Tx, it is necessary to understand the mechanism(s) by which natural and induced ABO Abs develop. Prior studies have used...
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An Exploration of the Cost of Liver Transplantation Using the OrganOx Normothermic Machine Perfusion in Comparison to Static Cold Storage in the Canadian Setting
DownloadFall 2021
Liver transplantation is life-saving but costly for the health care system, the patient and their caregivers. Over the last decade there has been a decrease in the available liver grafts leading to an increased use of extended criteria donors and an increase in the waitlist mortality rate. The...
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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Boxed-in: Comparing Algorithms for Box-flight Mass-Balance Greenhouse Gas Flux Measurements from Mineable and In Situ Oil Sands Developments
DownloadSpring 2022
To combat global warming, Canada has committed to reducing greenhouse gases (GHGs) 40-45% below 2005 emission levels by 2025. Monitoring emissions and deriving accurate inventories are essential to reaching these goals. GHGs can be measured at a small scale, often using ground measurements which...
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Content Validity of a Questionnaire Specifically Designed to Clinically Identify Pediatric Environmental Exposures
DownloadSpring 2014
Various clinical questionnaires exist to assist clinicians with the diagnosis, prognosis, long-term follow up of a disease, or even to assess quality of life. However, any questionnaire must be evaluated for its validity and reliability before application. Invalid or unreliable questionnaires can...
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Spring 2015
Cytomegalovirus (CMV) is the most common opportunistic post-transplant infection. Although important advances have been made in the management and prevention of post-transplant CMV, current strategies for monitoring and prevention still show significant limitations. Such gaps create opportunities...
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Developing clinically translatable chimerism induction protocols in a stringent murine model
DownloadSpring 2020
Allogeneic hematopoietic chimerism induction via bone marrow transplantation (BMT) is thus far the most robust method for inducing donor antigen specific tolerance to allogeneic grafts. However, limited by the toxicity of the reagents used in conditioning the recipients, the demand of a high dose...