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Skip to Search Results- 1Dahal, Abhishek
- 1Dalrymple, Ashley
- 1Kamtchum Tatuene, Joseph
- 1Tanase, Celestina S.
- 1Toossi, Amirali
- 1Wannamaker, Robert
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Alteration of astrocyte markers and phosphorylation of tau protein in kainic acid-treated animal model of Temporal Lobe Epilepsy
DownloadFall 2022
Kainic acid, an analogue of the excitatory neurotransmitter glutamate, when administered systemically can trigger seizures and neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (mTLE), which affects ~50million people globally. Evidence suggests that...
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Spring 2022
Carotid atherosclerosis is responsible for 15-25% of the nearly 8 million first-ever ischemic strokes that occur each year worldwide. This proportion has remained constant over the past three decades, thus suggesting that some patients with carotid atherosclerosis currently receive suboptimal...
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Fall 2020
Intracerebral hemorrhage (ICH), when a blood vessel ruptures within the brain, affects approximately 15% of stroke victims in Canada. There are no proven neuroprotective treatments ICH but two therapies, therapeutic hypothermia (TH) and iron-chelators, have gained preclinical and clinical...
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Spring 2019
Walking is a locomotor task that integrates information from all over the nervous system. The lumbosacral spinal cord houses neural networks that contribute to locomotion. These networks dominate locomotor activity during development and may provide suitable targets for restoring function after...
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Fall 2019
Background: Advancements in stroke imaging have allowed clinicians to more accurately select acute ischemic stroke patients for reperfusion therapies. This has moved patient selection from a time-based to an imaging-based paradigm. With few studies directly assessing the differences between...
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Towards Clinical Testing of Intraspinal Microstimulation for Restoration of Walking after Spinal Cord Injury
DownloadSpring 2019
The overall goal of this thesis was to advance intraspinal microstimulation (ISMS) towards clinical testing for the purpose of restoring walking after spinal cord injury. ISMS implants focus on restoring mobility after spinal cord injury by activating the intact spinal motor networks below the...