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Skip to Search Results- 27Alzheimer's disease
- 4Dementia
- 4Incidence
- 3Amyloid precursor protein
- 3Cognitive impairment
- 3Interventions
- 20Graduate and Postdoctoral Studies (GPS), Faculty of
- 20Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 8Nursing, Faculty of
- 6Nursing, Faculty of/Chronicity
- 1University of Saskatchewan
- 1University of Saskatchewan/Journal Articles (Saskatchewan)
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Data-Driven Approaches to Modeling Heterogeneity and Variability Across Asymptomatic Brain and Cognitive Aging, Mild Cognitive Impairment, and Alzheimer’s disease
DownloadSpring 2024
Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...
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2011
Innes, Anthea, Morgan, Debra, Kosteniuk, Julie
Objectives: The purpose of this review is to critically evaluate the available evidence from the published scientific literature on dementia care and service provision in rural and remote settings from the perspective of formal/paid caregiving, in order to assess the current state of knowledge,...
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Estimating the Seroprevalence of Cytomegalovirus (CMV), Epstein-Barr Virus (EBV) and the Risk of Transfusion-Transmitted and Community-Acquired CMV Infection in Solid Organ Transplant Donors and Recipients
DownloadFall 2019
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are ubiquitous herpesviruses that establish lifelong, often asymptomatic, infections in healthy people, but are responsible for significant morbidity and mortality in certain hosts. CMV is the most common congenital infection worldwide, causing...