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Skip to Search Results- 20Older adults
- 18Alzheimer's disease
- 4Cognitive impairment
- 3Amyloid precursor protein
- 2Amyloid beta
- 2Autophagy
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Assessment of food accessibility, availability and adherence to dietary recommendations among diabetic older adults living in subsidized retirement homes
DownloadSpring 2012
The availability and accessibility of healthy foods for type 2 diabetes patients may limit their food choices and adherence to dietary recommendations. The accessibility and availability of food for low-income, diabetic, older adults was evaluated. Information was gathered regarding self-care...
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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Fall 2013
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...
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Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...
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Data-Driven Approaches to Modeling Heterogeneity and Variability Across Asymptomatic Brain and Cognitive Aging, Mild Cognitive Impairment, and Alzheimer’s disease
DownloadSpring 2024
Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...