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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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Rural Older Adult Physical Activity Participation and Promotion in Cape Breton, Nova Scotia
DownloadFall 2012
Given the relatively high rates of physical inactivity among older adults in Nova Scotia (NS) (Statistics Canada, 2011), the purpose of this study was two-fold: 1. To examine the physical activity (PA) beliefs, perceptions and experiences of rural older adults in rural Cape Breton, NS and 2. To...
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Short- and Long-Term Impacts of A Working Memory Intervention for Children with Prenatal Alcohol Exposure
DownloadSpring 2018
This dissertation consists of two studies designed to: (1) determine the neurobehavioural profile reflecting the strengths and limitations of children with Parental Alcohol Exposure (PAE) and (2) evaluate the short- and long-term impacts of a 25-session Cogmed© intervention on improving working...
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Fall 2009
Social support is important for health and well-being and has been associated with reduced isolation in rural communities. Support from family and friends may become increasingly important as one ages, and may enable some seniors to remain living in their communities. The purpose of this project...
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Speech and Language Disorders in Older Canadians: Epidemiologic Primary Care-Based Research Using the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) Database
DownloadFall 2016
Objectives: The objective of this study is to examine the epidemiology and clinical management in primary care of speech and language disorders in older adults (fifty-five and older) and to assess the utility and feasibility of EMR data to answer such research questions. This study is comprised...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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The Effectiveness of Cognitive Behavioural Therapy for Secondary Prevention of Coronary Heart Disease: A Meta-Analysis
DownloadFall 2015
The effectiveness of secondary prevention (SP) for coronary heart disease (CHD) is well established. The poor integration of evidence into clinical practice remains problematic, in part due to the poor description of trials evaluating these programs. As a result, knowledge users remain unclear...
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The effectiveness of Return to Duty Intervention: Evaluating an interdisciplinary approach to supporting Canadian Armed Forces members who have physical and non-physical disorders
DownloadSpring 2016
The rate of musculoskeletal and mental health disorders is high in the Canadian Armed Forces, and can preclude service members from being employable and deployable. The aim of this thesis was to analyze the effectiveness of the Return to Duty intervention at decreasing morbidity and assisting...
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The Effects of Reading Interventions on the Word-Reading Performance of English Language Learners: A Meta-Analysis
DownloadFall 2017
Despite a large body of research on the effectiveness of reading interventions for monolingual English speakers, research on reading interventions for English language learners (ELLs) is still relatively scarce. Because the number of ELLs in schools is growing rapidly and these students often...