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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Fall 2013
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...
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Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...
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Data-Driven Approaches to Modeling Heterogeneity and Variability Across Asymptomatic Brain and Cognitive Aging, Mild Cognitive Impairment, and Alzheimer’s disease
DownloadSpring 2024
Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...
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Spring 2017
Coronary artery disease (CAD) is the leading cause of mortality in developed countries, followed by depression. Recent literature supports a bidirectional relationship between depression and CAD, which adversely affects the quality of life. Although there is a high prevalence of co-occurring CAD...
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Diminishing Returns in Cardiovascular Disease Research: Systematic Review and Meta-analysis
DownloadFall 2019
If “usual care” improves with time, it becomes increasingly difficult for new therapies to demonstrate additional benefit. Our objective then was to determine, by systematic review of randomized trials, whether the absolute cardiovascular risk reduction attributed to community-implemented...
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Effectiveness Evaluation Model for Frontline Worker Safety Intervention: An Exploratory Case Study of a Construction Prefabrication Company
DownloadFall 2016
Frontline foremen and workers play a critical role in implementing management’s safety policies and procedures. Despite the ultimate position in safety organization of frontline foremen and workers, variations in safety competency and acceptance level are often neglected, which leads to diverse...
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Spring 2024
Intracerebral hemorrhage (ICH), a devastating stroke caused by the rupture of vasculature in the brain, is responsible for <20% of all strokes, yet accounts for a disproportionately high burden of stroke related death and disability. The formation and degradation of the hematoma (blood clot)...
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Enrollment in Multidisciplinary Clinical Care for Pediatric Weight Management: Predictors, Reasons, Facilitators, and Recommendations
DownloadFall 2017
Background: One-third of Canadian children meet the criteria for overweight or obesity. While multidisciplinary clinical care (MCC) can be effective to manage pediatric obesity, many eligible children are not referred to this level of care and many of those who are referred do not enroll in...
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Fall 2011
With population aging, the ethnic diversity among older adults in Canada is of great significance as the main source of immigrants to Canada has shifted from Europe to Asia, Africa, and the Middle East. Researchers have pointed out the need to use an ethnno-cultural lens in order to address...