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Skip to Search Results- 1Al Onazi, Mona Moraybed
- 1Barrington, Catherine
- 1Benson, Curtis A
- 1Chang, Jihun
- 1Chenji, Sneha R.
- 1Clifford, Alexander M
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Relationships of Social Physique Anxiety and Behavioural Regulations to the Intention-Behaviour Gap Model
DownloadFall 2020
Given the increasing rate of inactive individuals, it is crucial that there is research focused on understanding the factors that may be related to lower exercise behaviour. A number of constructs are known to have a relationship with participation in exercise behaviour, including social physique...
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Respiration, Acid/Base, Ammonia and Ionoregulatory Strategies in the Pacific hagfish (Eptatretus stoutii)
DownloadFall 2016
Hagfish feed on putrefied carrion, which poses several environmental challenges to the scavenger including hypoxia (Low PO2), hypercapnia (high PCO2) and high environmental ammonia (HEA). To any other organism, these conditions would be physiologically challenging; however, hagfish seem to have...
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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Fall 2009
Skeletal muscle is a heterogeneous, multinucleated, post-mitotic tissue that contains many functionally diverse fibre types that are capable of adjusting their phenotypic properties in response to altered contractile demands. This plasticity, or adaptability of skeletal muscle is largely...
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Short- and Long-Term Impacts of A Working Memory Intervention for Children with Prenatal Alcohol Exposure
DownloadSpring 2018
This dissertation consists of two studies designed to: (1) determine the neurobehavioural profile reflecting the strengths and limitations of children with Parental Alcohol Exposure (PAE) and (2) evaluate the short- and long-term impacts of a 25-session Cogmed© intervention on improving working...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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The effect of aerobic fitness on the cardiovascular and sympathetic nervous system response to physiological stress at rest and during dynamic exercise
DownloadFall 2012
A cardio-protective adaptation associated with aerobic fitness may be an attenuated sympathetic nervous system (SNS) and cardiovascular response to stress. The hypothesis that the cardiovascular and SNS responses to physiological stress at rest and during exercise would be a function of...
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Spring 2010
The effects of exercise intensity on post-exercise measures of intestinal permeability and absorption in sedentary and in active young men were examined in this study. Measures were compared bewteen rest, low intensity and high intensity interval exercise interventions. In spite of the exercise...
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The Effectiveness of Cognitive Behavioural Therapy for Secondary Prevention of Coronary Heart Disease: A Meta-Analysis
DownloadFall 2015
The effectiveness of secondary prevention (SP) for coronary heart disease (CHD) is well established. The poor integration of evidence into clinical practice remains problematic, in part due to the poor description of trials evaluating these programs. As a result, knowledge users remain unclear...