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Characterization of Aerosol Deposition in Children and Infants Using Idealized Extrathoracic Geometries
DownloadFall 2014
This thesis describes a number of experimental studies performed with the common goal of characterizing pharmaceutical aerosol deposition in children and infants using idealized extrathoracic geometries. First, an in vitro study of the recently proposed Alberta Idealized Child Throat showed that...
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Characterizing the Mesolimbic Dopamine Reward Pathway in a Magel2-null Mouse, a Model of Prader-Willi Syndrome
DownloadFall 2016
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by extreme hyperphagia that can lead to severe obesity. The abnormal motivation to eat in PWS suggests a disruption in the hedonic feeding pathway, which is feeding based on reward as opposed to physiological need. Hedonic feeding is...
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Spring 2015
Colloidal-collector interactions are of fundamental importance in separation and filtration technologies. Here, the effect of collector grains on the behavior of colloidal particles was studied in two different experimental systems, i.e., column studies with stationary collectors and batch mixing...
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Fall 2011
The prevalence of childhood obesity has increased dramatically over the last three decades in Canada with substantial consequences for the physical, mental, and economic wellbeing of the population. The overarching objective of this thesis was to examine the various aspects of childhood obesity...
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Development of Conversation Cards for Adolescents©: A patient-centered communication and behavior change tool for adolescents with obesity and health care providers
DownloadFall 2019
Background. Given adolescents’ increasing desire for independence and autonomy, there is a need for research to examine their lived experiences, including concerns, preferences, and priorities. In the context of lifestyle modification for weight management, most adolescents with obesity exhibit...
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Development of Empirical Models to Predict Deposition of Aerosols in the Extrathoracic Airways of Children
DownloadSpring 2012
The experimental studies described in this thesis were performed with the goal of measuring deposition of aerosols, inhaled either nasally or orally, in the extrathoracic airways of children in different age groups. We pursued in vitro methods and characterized the deposition of aerosols in the...
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Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
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Fall 2012
Cardiometabolic syndrome refers to a clustering of several risk factors for cardiovascular disease; obesity and hyperlipidemia are two underlying disorders associated with the syndrome. An often overlooked aspect of these conditions is the effect that they may have on the pharmacokinetics of...
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Effect of Consuming Dairy Fats on Obesity-Related Cardiometabolic Perturbations and Immune Function in Low Birthweight Swine
DownloadSpring 2023
Although dairy intake has been shown to have a neutral or some beneficial effect on major cardiometabolic risk factors, the impact of dairy, and especially dairy fat, on immune function remains to be investigated. To understand the effect of consuming dairy fat on cardiometabolic risk factors and...
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Effect of gastric bypass and gastric banding on lipid absorption and their influence on glucose metabolism
DownloadFall 2011
Roux-en-Y gastric bypass (RYGB) leads to sustainable weight loss and resolution of hyperlipidemia and type 2 diabetes in obese patients. Its hypolipidemic effect is presumed to be based on fat malabsorption. Comparison of lipid absorption and insulin resistance following RYGB with adjustable...