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Skip to Search Results- 45Graduate and Postdoctoral Studies (GPS), Faculty of
- 45Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 18Oil Sands Research and Information Network (OSRIN)
- 9Oil Sands Research and Information Network (OSRIN)/AOSERP Reports
- 7Biological Sciences, Department of
- 7Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Spring 2017
Apoptosis serves as a powerful defense against damaged and unwanted cells. The family of Bcl-2 proteins plays a key role in the regulation of apoptosis at the mitochondria. Members of the Bcl-2 family include pro- and anti-apoptotic members that collectively determine the state of the cell....
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1979
Anderson, P. D., D'Apollinia, S., Perry, S., Dick, J., Deluca, J., Spear, P.
This study was initiated in early 1976 during the early stages of the Alberta Oil Sands Environmental Research Program. The goal of the project was the establishment of criteria safeguarding fish from toxic effects of mixtures of vanadium, nickel, and phenol to fish. All three constituents are...
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The Role of Forkhead Box Transcription Factors in Zebrafish Ocular Development and the Superior Ocular Fissure
DownloadFall 2014
Ocular development is a tightly orchestrated process that is dependent upon precise environmental and genetic factors. Disruption of this can result in microphthalmia, anophthalmia and coloboma (MAC), which is a spectrum of congenital ocular disease with lifelong consequences affecting sight. In...
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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Toxicity of saline groundwater from Syncrude's Lease 17 to fish and benthic macroinvertebrates
Download1977
Peltzner, A., McMahon, B., McCart, P., Walder, G.
The mining of the tar sands which are included in the area to be developed by Syncrude Canada Ltd. will require the dewatering of the mine pits. This will involve the pumping of large volumes of saline groundwater. Present plans call for its eventual disposal through Ruth Lake, the Poplar River...
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Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformation
Download2001
Chrenek, Micah A., Weaver, Valerie M., Wong, Paul
Stromal–epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered tissue organization, disrupted tissue...
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Spring 2016
Tamoxifen is the accepted therapy for patients with estrogen receptor α (ERα)−positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
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Uptake of waterborne selenite, and its toxic effects, in the water flea (Daphnia magna), Westslope cutthroat trout (Oncorhynchus clarkii lewisi) and rainbow trout (Oncorhynchus mykiss)
DownloadSpring 2024
Selenium is an essential element, playing an important role in many physiological processes. However, it possesses a narrow margin between essentiality and toxicity. In aquatic systems, selenium is increasingly identified as a trace element of major concern with levels exceeding regulatory...
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Using bioelectrical impedance analysis in children and adolescents: Pressing issues
2022-05-01
Orsso, Camila E., Gonzalez, Maria Cristina, Maisch, Michael Johannes, Haqq, Andrea M., Prado, Carla M.
Single- and multifrequency bioelectrical impedance analysis (BIA) has gained popularity as a tool to assess body composition and health status of children and adolescents, but many questions and misconceptions remain. This review addresses pressing issues researchers and health care providers may...