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2012

Guan, Leluo, Romao, Josue M., McAllister, Tim, He, Maolong, Jin, Weiwu

Background MicroRNAs (miRNAs) are a class of molecular regulators found to participate in numerous biological processes, including adipogenesis in mammals. This study aimed to evaluate the differences of miRNA expression between bovine subcutaneous (backfat) and visceral fat depots (perirenal...

2016

Karmazyn, Morris, Proctor, Spencer D., Mangat, Rabban, Gan, Xiaohong T., Bairwa, Suresh C., Rajapurohitam, Venkatesh

White adipocytes are known to function as endocrine organs by secreting a plethora of bioactive adipokines which can regulate cardiac function including the development of hypertrophy. We determined whether adipose tissue conditioned medium (ATCM) generated from the epididymal regions of normal...

2016-03-09

McAllister, Tim A., Wang, Ou, Plastow, Graham, Stanford, Kim, Liang, Guanxiang, Guan, Le L., Selinger, Brent

Super-shedder cattle are a major disseminator of E. coli O157:H7 into the environment, and the terminal rectum has been proposed as the primary E. coli O157:H7 colonization site. This study aimed to identify host factors that are associated with the super-shedding process by comparing...

2014

Basu, Urmila, Verma, Shiv, Rahman, Muhammad H., Deyholos, Michael K., Kav, Nat N. V.

Canola (oilseed rape, Brassica napus L.) is susceptible to infection by the biotrophic protist Plasmodiophora brassicae, the causal agent of clubroot. To understand the roles of microRNAs (miRNAs) during the post-transcriptional regulation of disease initiation and progression, we have...

2013

Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim

Adipose tissue plays a critical role in energy homeostasis and metabolism. There is sparse understanding of the molecular regulation at the protein level of bovine adipose tissues, especially within different fat depots under different nutritional regimes. The objective of this study was to...

Spring 2024

Kilic, Tolga

Atherosclerosis, characterized by arterial fat deposits, is the root cause of many cardiovascular diseases. Plaque deposition results from a series of events initiated by elevated plasma cholesterol, inflammation of the arterial wall, cholesterol uptake, macrophage-derived foam cell formation,...

2016

Rahman, Muhammad H., Megha, Swati, Joshi, Raj K., Basu, Urmila, Kav, Nat N. V.

Sclerotinia stem rot caused by Sclerotinia sclerotiorum affects canola production worldwide. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the regulation of gene expression in plants, in response to both abiotic and biotic stress. So far, identification of...

Spring 2018

Tat, Wilson

Our goal is to study the additional elements of the mechanism of steatosis underlying hepatitis C virus (HCV) infection. Human hepatoma Huh7.5 cells cultured in human serum (HS) were used as a model to study the development of steatosis. Huh7.5 cells grown in HS media were chosen to study the...

2013

Wickramarathna, Aruna D., Siloto, Rodrigo M. P., Mietkiewska, Elzbieta, Pan, Xue, Weselake, Randall J.

The oil from flax (Linum usitatissimum L.) has high amounts of α-linolenic acid (ALA; 18:3cisΔ9,12,15) and is one of the richest sources of omega-3 polyunsaturated fatty acids (ω-3-PUFAs). To produce ∼57% ALA in triacylglycerol (TAG), it is likely that flax contains enzymes that can efficiently...

2012

Wan, Zhongxiao, Beaudoin, Marie-Soleil, Castellani, Laura, Wright, David C., Ritchie, Ian, Chan, Catherine B.

Background Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise....