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Skip to Search Results- 3Fliegel, Larry
- 1Abdulrahman, Nabeel
- 1Aguilar, Hector N
- 1Bairwa, Suresh C.
- 1Baral, Pravas Kumar
- 1Beaudoin, Marie-Soleil
- 12Graduate and Postdoctoral Studies (GPS), Faculty of
- 12Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Biochemistry, Department of
- 2Biochemistry, Department of/Journal Articles (Biochemistry)
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Cardiomyocyte antihypertrophic effect of adipocyte tissue conditioned medium from rats and its abrogation by obesity is mediated by the leptin to adiponectin ratio
Download2016
Karmazyn, Morris, Proctor, Spencer D., Mangat, Rabban, Gan, Xiaohong T., Bairwa, Suresh C., Rajapurohitam, Venkatesh
White adipocytes are known to function as endocrine organs by secreting a plethora of bioactive adipokines which can regulate cardiac function including the development of hypertrophy. We determined whether adipose tissue conditioned medium (ATCM) generated from the epididymal regions of normal...
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Characterisation of novel potential phosphorylation sites in the tumour suppressor Merlin in Drosophila
DownloadFall 2014
Neurofibromatosis Type II is an inherited cancer that manifests as various tumours in the nervous system. Mutations and deletions in the tumour suppressor Merlin (moesin, ezrin, radixin-like protein) are linked to the development of the disease. The mechanism by which Merlin suppresses cell...
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Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation and anaphase entry
Download2012
Campbell, S.D., Homola, E.M., Fasulo, B., Yu, K.R., Hsieh, T.S., Sullivan, W., Koyama, C.
Defects in DNA replication and chromosome condensation are common phenotypes in cancer cells. A link between replication and condensation has been established, but little is known about the role of checkpoints in monitoring chromosome condensation. We investigate this function by live analysis,...
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Fall 2014
The vast majority of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ALCL) tumors carry the genetic translocation t(2;5)(p23;q35), leading to production of the constitutively active fusion tyrosine kinase NPM-ALK. NPM-ALK expression and its potent transformative properties...
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IL-6 indirectly modulates the induction of glyceroneogenic enzmes in adipose tissue during exercise
Download2012
Wan, Zhongxiao, Beaudoin, Marie-Soleil, Castellani, Laura, Wright, David C., Ritchie, Ian, Chan, Catherine B.
Background Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise....
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Investigating the roles of phosphorylation in modulating Argonaute 2 activity and localization
DownloadSpring 2017
RNA interference (RNAi) has enabled the study of gene function with unprecedented specificity and reliability. Almost twenty years after the discovery of RNAi, we now know that this process is carried out by a set of evolutionarily conserved proteins. In mammals, these proteins form part of the...
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Modification of pulse starch properties by nanoparticulation and phosphorylation techniques
DownloadFall 2021
The global demand for plant-based protein is fast growing. This has resulted in significant expansion of pulse grain fractionation and value-added processing operations that primarily focus on protein refining. Pulse starches, as the major by-product of those operations, remain underutilized...
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Spring 2011
The Reelin-Disabled-1 (Dab1) signaling pathway plays a key role in regulating neuronal positioning and synaptic plasticity. Binding of Reelin to its receptors induces tyrosine phosphorylation of the intracellular adaptor protein Dab1. Tyrosine-phosphorylated Dab1 not only rapidly transmits the...
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Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy
Download2015-01-01
Mohamed, Iman A., Gadeau, Alain-Pierre, Fliegel, Larry, Lopaschuk, Gary, Mlih, Mohamed, Abdulrahman, Nabeel, Filmore, Natasha, Mraiche, Fatima
Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin (OPN) expression in models of cardiac hypertrophy (CH), and the...