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Fall 2015
This thesis consists of 2 closely linked projects that evaluate the importance of depressive symptoms (hereafter, for brevity, referred to as “depression”) for short-term prognosis after general medical hospitalizations. Project 1 systematically reviews the literature to examine whether...
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Mapping intracellular cytokine pools in granulocytes: Dynamic storage and trafficking sites of interleukin-9 and interleukin-13 in human eosinophils
DownloadFall 2020
Eosinophils are immune cells with constantly evolving roles in both innate and adaptive immunity and have long been associated with the predominant pathology of the human airways, asthma. Eosinophils are specialized in their granulocytic nature, possessing several membrane-bound secretory...
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Respiratory Syncytial Virus infection biases the immune response in favor of Th2: the role of Indoleamine 2, 3-dioxygenase
DownloadSpring 2012
Infants that develop severe bronchiolitis due to Respiratory Syncytial Virus (RSV) are at increased risk of developing asthma later in life. To begin my studies in vitro, purified RSV stock was needed. My first study established the critical steps in RSV purification to determine a procedure that...
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The Role of Vitamin D in Anti-Tumor Necrosis Factor-Alpha-Induced Response in Patients with Inflammatory Bowel Disease
DownloadFall 2014
Vitamin D is an important immunomodulator of the immune system and has been suggested to play a role in the pathogenesis of inflammatory bowel disease (IBD). Drugs targeting TNF-alpha are effective IBD therapies, and vitamin D has been demonstrated to suppress TNF-alpha as well as work...
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Fall 2014
Epidemiological studies correlate vitamin D deficiency with asthma severity. Calcitriol modulates receptor and cytokine expression from various leukocytes in an anti-inflammatory manner. Despite eosinophil activity during mucosal inflammation, knowledge on the direct effect of calcitriol on this...