Search
Skip to Search Results- 1Acedo, Jeella Z
- 1Cochrane, Stephen A.
- 1Ho, Linda
- 1Hosseini, Seyedeh Nargess
- 1Jensen, Lionel D
- 1Li, Lin
-
Fall 2014
Paenibacillus polymyxa NRRL B-30509, Paenibacillus terrae NRRL B-30644 and P. polymyxa NRRL B-30507 were found to produce several bacteriocins and non-ribosomal peptides. All three strains produce tridecaptins, non-ribosomal lipopeptides antimicrobially active against food pathogen Campylobacter...
-
Spring 2018
Acidocin B (AcdB), a bacteriocin from Lactobacillus acidophilus M46 that was initially reported to be a linear peptide, was purified and shown to be circular based on MALDI-TOF MS and MS/MS sequencing. MS analysis further revealed that AcdB is comprised of 58 amino acid residues, instead of 59...
-
Synthesis and biological evaluation of the lantibiotic peptide lactocin S and its analogues
DownloadSpring 2012
Lantibiotics (lanthionine containing antibiotics) are highly post-translationally modified peptides used by bacteria as a form of chemical warfare. In light of the challenges faced today in the field of antibacterial therapy, these potent natural products are useful lead compounds for the...
-
The [1,2]-Stevens Rearrangement of Oxonium Ylides: Synthetic Applications and Mechanistic Studies
DownloadSpring 2016
The Stevens [1,2]-rearrangement of onium ylides has been employed as a valuable synthetic method to construct new C-C bonds. Oxonium ylides are reactive intermediates that undergo facile Stevens rearrangement under mild conditions. In the last several decades, the Stevens rearrangement of oxonium...
-
The mechanism of action of cidofovir and (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine against viral polymerases
DownloadFall 2009
The nucleoside phosphonates cidofovir (CDV) and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [(S)-HPMPA] are analogs of dCMP and dAMP, respectively. Collectively these drugs are effective inhibitors of a wide range of DNA viruses, RNA viruses, and retroviruses. Because they are nucleotide...
-
Thin Film Point of Care Diagnostic and the Potential Mitigation of Antimicrobial Resistance
DownloadFall 2021
Antimicrobial resistance is an emerging worldwide threat that endangers the effectiveness of many of the gains of modern medicine. Therapies are becoming less effective through their overuse even while antimicrobial stewardship programs have been developed to measure and improve how antibiotics...
-
Treatment of Antiviral Drugs in Wastewater Using Advanced Oxidation Processes - Ozonation of Oseltamivir Phosphate
DownloadFall 2021
While wastewater treatment facilities are designed to remove contaminants from water before it returns to the environment, unfortunately, not all of these facilities are effective in the removal of micropollutants (MPs). Antiviral drugs are a class of MPs that have become an area of concern due...