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Skip to Search Results- 3Chan, Catherine B.
- 3Wheeler, Michael B.
- 2Dai, Feihan F.
- 2Koshkin, Vasilij
- 1Braunewell, Karl-Heinz
- 1Gaisano, Herbert Y.
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A member of the neuronal Ca2+-sensor protein family visinin-like-protein-1 (vilip-1) is expressed in pancreatic β-cells and regulates insulin secretion and biosynthesis
Download2006
Gaisano, Herbert Y., Braunewell, Karl-Heinz, Dai, Feihan F., Chan, Catherine B., Wang, Qinghua, Kang, Youhou, Wheeler, Michael B., Zhang, Yi
Visinin-like protein-1 (VILIP-1) is a member of the neuronal Ca2+ sensor protein family that modulates Ca2+-dependent cell signaling events. VILIP-1, which is expressed primarily in the brain, increases cAMP formation in neural cells by modulating adenylyl cyclase, but its functional role in...
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2004
Zhang, Chen-Yu, Chan, Catherine B., Koshkin, Vasilij, Wheeler, Michael B., Lowell, Bradford B., Joseph, Jamie W., Saleh, Monique C., Sivitz, William I.
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–)...
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Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic ß-cells
Download2008
Wheeler, Michael B., Chan, Catherine B., Dai, Feihan F., Koshkin, Vasilij, Robson-Doucette, Christine A.
Involvement of the mitochondrial permeability transition (MPT) pore in early stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was the focus of this study. Both long term (indirect) and acute (direct) effects of fatty acid (FA) application on β-cell susceptibility to...