Patient engagement in the design of an intervention to prevent muscle loss in individuals with knee osteoarthritis and a BMI ≥35

• Author(s) / Creator(s)

  • Godziuk, Kristine
  • Prado, Carla M.
  • Forhan, Mary

• Objective Interventions for knee osteoarthritis (OA) in adults with a large body size [defined as a BMI≥35 kg/m2] often prioritize weight-loss, which may overshadow specific benefits for physical function, metabolic health, and body composition. As part of the development of a future clinical study, we gathered perspectives from individuals living with knee OA and a large body size to inform the proposed intervention design and delivery.
  Methods Purposive and voluntary sampling was used to engage individuals ≥40 years of age with self-reported knee OA and a BMI≥35 kg/m2. An anonymous electronic survey was distributed on social media between April-June 2020. Open-ended questions addressed a proposed 12-week multimodal intervention (involving targeted nutrition, resistance exercises, and self-management support). An optional semi-structured interview was offered upon completion, with interviews recorded and transcribed verbatim. Reflexive thematic analysis and interpretation guided by an acceptability framework was used to identify recommendations for the intervention design and delivery.
  Results Twenty individuals living across Canada completed the survey (100% female; 18 aged <65 years and 2 ≥65 years). Ten individuals completed the interview. From aggregate survey and interview data, three recommendations were generated: 1) the effectiveness of the intervention for health improvement (specifically mobility and pain) must be emphasized to avoid perceived weight-loss expectations; 2) extend support beyond 12-weeks and consider terminology free from weight-bias to enhance acceptance; 3) include optional customization of intervention delivery to reduce acceptability-related burden.
  Conclusion These female patient-derived recommendations may improve perceived intervention acceptability, and thereby may enhance participant enrollment and retention in clinical trials.

• Date created

  2021-12-21

• Subjects / Keywords

  • Osteoarthritis
  • body mass index
  • obesity
  • patient-and-public involvement
  • qualitative

• Type of Item

  Article (Published)

• DOI

  https://doi.org/10.7939/r3-aa58-yq77

• License

  "This is the peer reviewed version of the following article: [Godziuk K, Prado CM, Forhan M. (2022). Patient engagement in the design of an intervention to prevent muscle loss in individuals with knee osteoarthritis and a body mass index (BMI) ≥ 35. Musculoskeletal Care. doi: 10.1002/msc.1613.], which has been published in final form at [https://doi.org/10.1002/msc.1613]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."