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Portable and Wearable Biomedical Devices for Pre-diagnosis, Detection, and Treatment
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- Author / Creator
- Ye, Xuanjie
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This dissertation explores portable, wearable biomedical devices, focusing on bioimpedance and low-intensity pulsed ultrasound (LIPUS) for pre-diagnosis, detection, and treatment. It includes five studies, three on bioimpedance and two on LIPUS. First, in the bioimpedance area, this dissertation investigates the feasibility of using bioimpedance measurement with a bipolar electrode configuration for knee injury assessment, demonstrating its potential for knee injury detection and monitoring. The second study presents an electrochemical impedance spectroscopy (EIS) based method for biomarker detection with the anti-SARS-CoV-2 IgG antibody being used as the biomarker in the study. The results show that this method can offer rapid response, high sensitivity, and minimal sample requirements. After that, the third study introduces the development of a portable, low-cost EIS system for point-of-care (POC) testing, showcasing excellent accuracy and precision in biosample measurements. Within the LIPUS domain, an interface chip for miniaturized LIPUS driver systems is presented. This chip integrates multiple modules onto a single chip so as to ensure the compatibility and low cost of the system. With an inductor-free design, the chip can be magnetic resonance imaging (MRI) compatible. The last study explores the effect of LIPUS with various parameter settings on promoting neuronal growth and nervous system regeneration. In sum, this dissertation advances portable and wearable biomedical devices, with significant implications for bioimpedance and LIPUS technologies in early diagnosis, biomarker detection, and treatment.
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- Subjects / Keywords
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- Graduation date
- Fall 2023
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- Type of Item
- Thesis
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- Degree
- Doctor of Philosophy
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- License
- This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.