CMOS Instrumentation for Genetic Analysis Lab-on-a-Chip

  • Author / Creator
    Martin, Benjamin R
  • One application for lab-on-a-chip (LOC) devices is performing miniaturized laboratory tests. These devices would be ideal for point-of-care medical diagnostic applications; however, many still rely on external bench-top instrumentation. It is logical to shrink this instrumentation as well. In this dissertation we discuss a mixed-signal CMOS implementation of the instrumentation for a genetic analysis LOC. Many genetic analysis methods rely on the detection of faint fluorescent signals and the use of high voltages. For this reason, special attention is given to the design of the photodiode amplifiers and analog-to-digital converter in a 5V/300V 800nm CMOS process. As part of this work, we have demonstrated a 2nd-order delta-sigma modulator with a bandwidth of 1.2kHz, and an SNR of 78dB. Also, we present a novel differential fluorescent detection scheme for capillary electrophoresis that uses two photodiodes to dynamically remove the baseline signal caused by excitation light.

  • Subjects / Keywords
  • Graduation date
    Spring 2012
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.