Percutaneous vertebroplasty for osteoporotic vertebral compression fracture

  • Author / Creator
    Golmohammadi, Kamran
  • Background: Current vertebroplasty practices significantly vary due to differences in perceived effectiveness and safety of this interventional approach. Objectives: To assess the efficacy and safety of Percutaneous Vertebroplasty in relieving pain due to osteoporotic vertebral compression fracture. Methods: We conducted a systematic review. Randomized controlled trials were included in the efficacy review. All reports of major adverse effects were included in the safety review. We also included reports of minor adverse effects from studies of 30 consecutive cases or more. Results: Vertebroplasty had no advantage over conservative management in improving pain, disability and Health-Related Quality of Life (HR QOL), with the exception of HR-QOL at 1 month. Mortality and major adverse events following vertebroplasty are rarely reported. Conclusion: Decision to perform Percutaneous Vertebroplasty should be based on criteria that include a clear definition of conservative therapy and its failure prior to proceeding with the procedure.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.