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Investigation of Hsp90 Regulation by the Aha-type Co-chaperones: Mechanistic Insight into Two Conserved MotifsDownload
Hsp90 is a highly conserved and essential molecular chaperone. It regulates the folding, maturation, and activation of client proteins involved in a wide range of cellular processes and pathways, many of which are key players in disease. Hsp90 functions in the context of an ATPase driven...
Mast cells (MCs) are tissue resident innate immune cells. They are recognized for their immunoregulatory roles in the regulation of innate and adaptive immunity. Aberrant activation and responses of MCs result in inflammatory disorders like allergies. Thus, the biological pathways that control MC...
Understanding the evolution of the membrane trafficking system in diverse eukaryotes through comparative genomics and transcriptomicsDownload
Single-celled organisms represent the majority of eukaryotic diversity. Recent advances in sequencing technologies have been critical for understanding the evolutionary biology and cell biology of microbial eukaryotes. Comparative genomic analyses have shown that many genes that underlie...