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In Situ Synthesis of CuS Nanoparticle Doped Poly (N-isopropylacrylamide)-Based Microgels for Near-Infrared Triggered Photothermal Therapy
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- Author(s) / Creator(s)
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Poly(N-isopropylacrylamide)-co-(acrylic acid) (pNIPAm-co-AAc) microgels incorporated with CuS nanoparticles (CuSNPs) were synthesized and employed for near-infrared (NIR) triggered photothermal killing of cancer cells. Cu2+ was enriched in the microgels through deprotonation of the pNIPAm-co-AAc microgels at high solution pH. CuSNPs were subsequently generated within the pNIPAm-co-AAc microgels upon exposure to heat and S2–. The solution of hybrid microgels showed an absorption peak in the NIR region (∼1000 nm). After demonstrating that the hybrid microgels were not cytotoxic, we showed that NIR excitation of the hybrid microgels could be used to kill HeLa cells. Almost 90% of the HeLa cells were killed when incubated with 400 μg/mL of the hybrid microgels and exposed to 808 nm laser light with a power density of 2 W/cm2 for 10 min. While these materials show promise for photothermal therapy, they can also be incorporated into a hydrogel matrix that can be triggered to release small molecule drugs upon exposure to NIR wavelengths.
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- Date created
- 2018-01-01
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- Type of Item
- Article (Draft / Submitted)
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- License
- © American Chemical Society, 2018. This is an open access article which is free to download and share.