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Longitudinal performance of Neuropsychological Assessments in Parkinson’s Disease.

  • Author / Creator
    Muayqil, Taim
  • Parkinson’s disease (PD) involves the motor system and can lead to dementia. Dementia incidence among 102 non-demented participants (52 PD and 50 controls) followed prospectively over three years was assessed. Cognition was measured annually using the Clock Drawing Test (CDT), Mini-Mental State Exam (MMSE), Frontal Assessment Battery (FAB) and Dementia Rating Scale (DRS). Mixed-effects model was used to determine the significance of the change in neuropsychological tests (NPT) over time. Incidence of dementia in the PD group was 41.67%. The FAB and DRS showed significant. In the PD subgroup, the copy-CDT (CCDT), FAB and DRS showed decline in patients with incipient dementia (PDID). The FAB and DRS scores correlated in the primary and subgroup analyses. In the subgroup, the CCDT correlated with FAB and DRS. The NPT were useful in discriminating PD from control patients with early cognitive impairments and discriminating PDID from PDND.

  • Subjects / Keywords
  • Graduation date
    2012-09
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R37W81
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • School of Public Health Sciences
  • Specialization
    • Clinical Epidemiology
  • Supervisor / co-supervisor and their department(s)
    • Camicioli, Richard (Medicine)
    • Senthilselvan, Ambikaipakan (Public Health Sciences)
  • Examining committee members and their departments
    • Jeerakathil, Thomas (Medicine)
    • Kalra, Sanjay (Medicine)
    • Camicioli, Richard (Medicine)
    • Senthilselvan, Ambikaipakan (Public Health Sciences)