[(tert-Butyldimethylsilyl)oxy]methanethiol and [(tert-Butyldiphenylsilyl)oxy]- methanethiol—Nucleophilic Protected H2S Equivalents

• Author(s) / Creator(s)

  • Dong, Shuai
  • Clive, Derrick L. J.
  • Gao, Jin-Ming

• [(tert-Butyldimethylsilyl)oxy]methanethiol [HSCH2OSiMe2Bu-t] is a nucleophilic reagent for
  2
  introduction of a protected bivalent sulfur; this reagent is complementary to the electrophilic reagent p-MeC6H4SO2SCH2OSiMe2Bu-t. The thiol is prepared by the action of HSLi on tert-butyl(chloromethoxy)dimethysilane [ClCH2OSiMe2Bu-t] and it reacts with alkyl bromides to give protected thiols.

• Date created

  2015-01-01

• Subjects / Keywords

  • sulfur protection
  • protection of sulfur
  • thiol
  • hydrogen sulfide equivalent

• Type of Item

  Article (Draft / Submitted)

• DOI

  https://doi.org/10.7939/r3-zmts-6a67

• License

  Attribution-NonCommercial-NoDerivatives 4.0 International