Comparative investigation on clinical trial designs

  • Author / Creator
    Wang, Jing
  • A number of interesting subjects relevant to optimality of design, cost efficiency evaluation, and the adaptive treatment allocation for response-adaptive repeated measurement designs have been reviewed and discussed. First we introduce some optimal crossover designs, and compare those designs with completely randomized trials and N-of-1 trials in terms of their relative design efficiency and cost saving, followed by a discussion of three statistical models for repeated measurement designs. Then the response-adaptive design in comparison with standard randomized clinical trials has been elaborated. An adaptive treatment allocation scheme for a multiple-objective response-adaptive repeated measurement design is presented in detail; and the simulation study illustrates how the adaptive treatment allocation scheme works efficiently to simultaneously achieve two objectives: increasing estimation precision and treatment benefit.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Department of Mathematical and Statistical Sciences
  • Supervisor / co-supervisor and their department(s)
    • Dr. Keumhee Carriere Chough
  • Examining committee members and their departments
    • Dr. Pengfei Li
    • Dr. Sunita Vohra