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Clinical and Angiographic Outcomes Associated with Surgical Revascularization of Angiographically Borderline 50-69% Coronary Artery Stenoses

  • Author / Creator
    Senaratne, Janek M
  • Objectives: Coronary artery bypass grafting improves outcomes in patients with multi-vessel coronary artery disease. Bypass of angiographically significant lesions ≥70% is recommended, yet little is known about the incidence/outcomes with bypasses of 50-69% angiographically borderline lesions without fractional flow reserve testing. The objective of this study was to investigate the incidence and outcomes of bypass of 50-69% angiographically borderline lesions. Methods: Between 2007 and 2013, 3,195 patients underwent isolated first multi-vessel coronary artery bypass grafting at the Mazankowski Alberta Heart Institute. Patients with an isolated angiographically borderline lesion of a major epicardial vessel were included. The primary analysis compared clinical and angiographic outcomes between patients with and without coronary bypasses of angiographically borderline lesions. Outcomes of interest included time to all-cause mortality, 30 day, and 1 year mortality. Results: Among 350 patients with an angiographically borderline lesion, 268 (76.6%) had the vessel containing the angiographically borderline lesion bypassed while 82 (23.4%) did not. Mean follow-up was 4.2 years. Patients with a bypassed angiographically borderline lesion were older (66.1 vs 62.5 mean years, p=0.006) but otherwise similar in sex, comorbidities, diabetes, ejection fraction, and number of coronary stenoses. Cardiopulmonary bypass time was longer in patients with bypassed angiographically borderline lesions (104.2 versus 90.4 minutes, mean, p<0.001). Unadjusted overall mortality through end of follow-up was higher among patients with bypassed angiographically borderline lesions (11.6% versus 3.7%, p=0.034). After multi-variable adjustment, the association between angiographically borderline lesion bypass and mortality was attenuated (hazard ratio 2.84: 95% confidence interval, 0.87 – 9.23, p=0.080). No differences were observed in unadjusted 30-day (1.1% versus 0.0%, p=0.336) or 1-year mortality (4.1% versus 0.0%, p=0.062). Repeat revascularization of patients with bypassed angiographically borderline lesions was numerically higher (4.1% versus 0.0%, p = 0.107). Conclusions: In an unselected cohort of patients with angiographically borderline lesions, bypass of borderline 50-69% lesions is frequently performed and not associated with improved long-term survival. Our findings suggest that the routine surgical revascularization of 50-69% angiographically borderline lesions may not be warranted.

  • Subjects / Keywords
  • Graduation date
    2017-11:Fall 2017
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3N58D08B
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Medicine
  • Specialization
    • Translational Medicine
  • Supervisor / co-supervisor and their department(s)
    • Dr. Craig Butler, Department of Medicine
    • Dr. Sean Van Diepen, Department of Critical Care Medicine
  • Examining committee members and their departments
    • Dr. Dave Zygun, Department of Critical Care Medicine
    • Dr. Jeevan Nagendran, Department of Surgery