A Route to Polyprenol Pyrophosphate-Based Probes of O- Polysaccharide Biosynthesis in Klebsiella pneumoniae O2a

• Author(s) / Creator(s)

  • Ryan P. Sweeney
  • Todd L. Lowary

• An approach for the assembly of polyprenol pyrophosphate-based probes of O-polysaccharide biosynthesis in Klebsiella pneumoniae serotype O2a is described. This convergent route features high yielding, diastereoselective glycosylations and the late stage installation of the polyprenol pyrophosphate moiety. Although applied to the synthesis of a nonasaccharide bear- ing a farnesyl group (1), the modular nature of the route makes it amenable to the synthesis of additional derivatives containing either larger glycans or different lipid domains.

• Date created

  2019-01-27

• Subjects / Keywords

  • Synthesis, lipopolysaccharide, probe

• Type of Item

  Article (Published)

• DOI

  https://doi.org/10.7939/R38W38J79

• License

  Attribution-NonCommercial 4.0 International