Bioinspired Strategies to Develop Dual-Functional Polymer-Based Antibacterial Coatings for Biomedical Applications

• Author / Creator

  Imbia, Adel S M

• The main objective of this thesis is to construct bifunctional coatings by combining the functional polymers with tannic acid, dopamine, and dopamine methacrylate via strong covalent bonds to enhance the mechanical stability of the coatings. Hydrophilic polymers and bactericidal agents have been exploited to prepare stable dual-functional coatings for biomedical applications. Three different objectives have been developed in this thesis as follows: 1) A simple dip-coating method using tannic acid chemistry was used to develop a
  superhydrophilic coating with antifouling and antibacterial properties. 2) stable contact-killing coating was developed, which killed the bacteria even after immersion in PBS for 7 days, using a simple co-deposition process. The functional copolymers were then covalently grafted to the amino
  groups of polydopamine-coated surfaces and exhibited excellent antibacterial properties against S. aureus and E. coli and antifouling properties against bovine serum albumin (BSA) protein. 3) A copolymer containing glycopolymer with fouling-resistance properties was incorporated with copper ions via metal-phenol networks (MPNs) to fabricate a coating with high antifouling properties and stability.

• Subjects / Keywords

  • Tannic acid
  • Polydopamine
  • Antibacterial
  • Antifouling
  • Nanoparticles
  • Copolymer
  • Coating
  • Surfaces

• Graduation date

  Fall 2024

• Type of Item

  Thesis

• Degree

  Doctor of Philosophy

• DOI

  https://doi.org/10.7939/r3-qey1-ae52

• License

  This thesis is made available by the University of Alberta Library with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.