Response of Lipid Olefinic Protons to In-Vivo Magnetic Resonance Spectroscopy Sequences at 3 T

  • Author / Creator
    Bingolbali, Ayhan
  • Magnetic Resonance Spectroscopy (MRS) measurements of lipid unsaturation are relevant in the study of a number of diseases. The olefinic resonance yields a measure of lipid unsaturation and is often obscured by water signal in-vivo. The objective of this work is to investigate the response of lipid olefinic protons to STEAM, one of two standard in-vivo MRS methods (the other being PRESS). STEAM timing parameters were chosen (mixing time = 20 ms, echo time = 100 ms) to sufficiently resolve the olefinic resonance from that of water in-vivo while ensuring that it did not suffer significant signal losses due to J-coupling. The optimized STEAM sequence was employed to acquire signal from spinal bone marrow of four volunteers, and on average it provided 91% more olefinic signal (by area) compared to the signal acquired with a previously optimized PRESS sequence at 3 T.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Department of Oncology
  • Specialization
    • Medical Physics
  • Supervisor / co-supervisor and their department(s)
    • Yahya, Atiyah (Oncology)
  • Examining committee members and their departments
    • Jans, Hans-Sonke (Oncology)
    • Wilman, Alan (Biomedical Engineering)
    • De Zanche, Nicola (Oncology)
    • Yahya, Atiyah (Oncology)
    • Fallone, Gino (Oncology)