ERA is in the process of being migrated to Scholaris, a Canadian shared institutional repository service (https://scholaris.ca). Deposits and changes to existing ERA items and collections are frozen until migration is complete. Please contact erahelp@ualberta.ca for further assistance
- 254 views
- 465 downloads
Efficient Cardiac Cell Solvers and Simulating Temperature Dependence in the Myocardium
-
- Author / Creator
- Grenier, Justin G
-
The modelling of the electrical activity in cardiac tissue can enable researchers
to study heart phenomena such as arrhythmias which are difficult to observe in vivo. However, the nature of the mathematical equations used to represent these behaviors present multiple numerical difficulties which limit their large scale usage. In this thesis, we have suggested the application of a nested implicit Runge-Kutta method of order 4 (NIRK4) as a means of efficiently solving the stiff cardiac cell models. By comparing its performance to multiple common implicit and explicit solvers, we have established the advantages of using NIRK4 when solving multiple cell models of varying complexities.
Due to recent experimental and modelling results, it was deemed advantageous
to investigate the effects of the temperature on the transmembrane potential.
Therefore, we developed a mathematical model by coupling Pennes' bioheat
equation to the bidomain model to simulate the induced heat caused by cardiac
action potential. The influence of the temperature on ionic conductances
in the Aliev-Panfilov and Luo-Rudy cardiac cell models was also investigated.
Furthermore, the induced heat caused by the transmembrane potential's propagation
was studied as a potential method for detecting spiral-waves. -
- Graduation date
- Fall 2014
-
- Type of Item
- Thesis
-
- Degree
- Master of Science
-
- License
- This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.