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Vitamin D Supplementation and Bone Health in Adults with Diabetic Nephropathy: Preliminary Findings from a Randomized Controlled Trial

  • Author / Creator
    Schwindt, Stephanie T
  • Vitamin D (vitD) is a nutrient of concern in Canada particularly for those with diabetes and chronic kidney disease (CKD). Participants (18-80y) with diabetes and CKD were randomized to receive either 50mcg/day (n=33) or 1,000mcg/month (n=30) vitD3 for 6-months. Variables studied included: anthropometric/demographic data, routine clinical blood work, serum/plasma 25(OH)D, 1,25(OH)2D, PTH, bone turnover markers (BTM), and vitD intake. No significant differences in clinical characteristics between groups or study visits were observed (p>0.05). Adherence to daily and monthly supplementation was 93% and 100%, respectively. Mean 25(OH)D and 1,25(OH)2D concentrations increased in both groups after 6-months; but significant increases in 25(OH)D were seen only in the daily group (78.4 to 95.1nmol/L; p=0.01). There were no significant differences between groups over 6-months in PTH or BTM (p>0.05). This suggests that both once daily and once monthly vitD supplementation strategies are equally effective at influencing vitD status despite differences in adherence.

  • Subjects / Keywords
  • Graduation date
    2013-11
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3Z09Z
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Agricultural, Food, and Nutritional Science
  • Specialization
    • Nutrition and Metabolism
  • Supervisor / co-supervisor and their department(s)
    • Mager, Diana (Agricultural, Food, and Nutritional Science)
  • Examining committee members and their departments
    • Field, Catherine (Agricultural, Food, and Nutritional Science)
    • Senior, Peter (Medicine)
    • McCargar, Linda (Agricultural, Food, and Nutritional Science)