Cumulative Total Incidence for Estimating the Burden of Recurrent Events and Risk vs. Rate Concepts and Regression Models in Epidemiology

  • Author / Creator
    Dong, Huiru
  • In the first part of this thesis, a straightforward intuitive method for descriptive survival analysis, termed “cumulative total incidence”, is proposed to measure the total burden of recurrent events in a population by a given time. Using data from the Childhood Cancer Survivor Study, demonstrate the utility of this method contrasting this method to cumulative incidence. In the second part of this thesis, the concepts of risk and rate, and their relationship are discussed in the framework of survival analysis. Regression approaches for estimating the association between factors on event risk and event rate are discussed. Using data from the Childhood Cancer Survivor Study on two competing outcomes, we further demonstrate how competing-risk event affects the estimated association of covariates of interest with event risk and rate.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • School of Public Health Sciences
  • Specialization
    • Epidemiology
  • Supervisor / co-supervisor and their department(s)
    • Yasui, Yutaka (School of Public Health)
  • Examining committee members and their departments
    • Yuan, Yan (School of Public Health)
    • Jhangri, Gian (School of Public Health)