Formation of Enol Ethers by Radical Decarboxylation of α-Alkoxy β-Phenylthio Acids

• Author(s) / Creator(s)

  • Palanivel, Ashokkumar
  • Mubeen, Sidra
  • Warner, Thomas
  • Ahmed, Nayeem
  • Clive, Derrick, L.J.

• Enol ethers are formed by radical decarboxylation of α-alkoxy β-phenylthio acids via the corresponding Barton esters. The phenylthio acids were usually made by the known regioselective reaction of α,β-epoxy acids with PhSH in the presence of InCl3, followed by O-alkylation of the resulting alcohol. In one case, thiol addition to an α,β-unsaturated ethoxymethyl ester was used.

• Date created

  2019-08-29

• Subjects / Keywords

  • Enol Ethers
  • Barton Esters
  • Α-Alkoxy Β-Phenylthio Acids
  • Radical Decarboxylation

• Type of Item

  Article (Draft / Submitted)

• DOI

  https://doi.org/10.7939/r3-qfm0-hg45

• License

  © American Chemical Society, 2019. This is an open access article which is free to download and share.