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The Clinical Adoption of anti-CD19 CAR T-cell Therapy in Alberta: A Historical Review and Retrospective Comparative Case Study
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- Author / Creator
- Breckenridge, Zackariah
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This thesis details the adoption of anti-CD19 CAR T-cell therapy in Alberta from 2018-2021, during which time a commercial (tisagenlecleucel) and investigative (ACT-C01) CAR T product were implemented as standard of care and under a clinical trial, respectively. Information was gathered through stakeholder interviews, primary source documents obtained from Alberta Health Services employees involved in the adoption process, and peer-reviewed and grey literature acquired by targeted database searches. Herein, we provide a timeline of the events and processes at both centres; a comprehensive list of the stakeholders and their relationships; and an analysis of the challenges of and enablers to adoption using the Consolidated Framework for Implementation Research. Potential approaches to assessing the outcomes of the adoption process across each site from a health system perspective are proposed, and lastly, limitations of the study are acknowledged and future research avenues proposed.
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- Subjects / Keywords
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- Graduation date
- Fall 2022
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- Type of Item
- Thesis
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- Degree
- Master of Science
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- License
- This thesis is made available by the University of Alberta Library with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.