Synthesis of models of the BC ring systems of MPC1001 and MPC1001F

• Models of the BC ring systems of MPC1001 and MPC1001F†

• Author(s) / Creator(s)

  • Dong, Shuai
  • Indukuri, Kiran
  • Clive, Derrick L. J.
  • Gao, Jin-Ming

• Piperazinedione 13, representing the BC ring system of the anti-prostate cancer
  fungal metabolite MPC1001 was prepared by a route in which a sulfur-stabilized carbanion
  derived from 22 cyclizes onto the terminal ester of the chain attached to N1. Another model, 14,
  was synthesized by cyclization of an -ketoamide nitrogen onto an ester; 14 represents the BC
  rings of MPC1001F.

• Date created

  2016-01-01

• Subjects / Keywords

  • antineoplastic agent
  • mpc 1001
  • mpc 1001f
  • piperazinedine
  • unclassified drug

• Type of Item

  Article (Draft / Submitted)

• DOI

  https://doi.org/10.7939/r3-x2td-w532

• License

  Attribution-NonCommercial 4.0 International