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- 20Spinal cord injury
- 4Functional electrical stimulation
- 2Corticospinal tract
- 1Alvarado, Laura
- 1Bamford, Jeremy, Andrew
- 1Bergquist, Austin J
- 1Clair, Joanna
- 1D'Amico, Jessica M
A pilot study investigating arm and leg FES-assisted cycling as an intervention for improving ambulation after Incomplete Spinal Cord InjuryDownload
People with incomplete spinal cord injury (iSCI) have the potential for recovering walking through plasticity-induced changes in the remaining neural circuitry. Current rehabilitation for walking attempts to induce such changes by providing relevant sensory inputs and motor commands through...
Spinal cord injury (SCI) is an extremely debilitating condition, leading to sensory and motor dysfunction below the level of the injury. Presently, there are few effective treatments for SCI. This is in part due to the immense complexity of SCI pathophysiology. Thus, combined research approaches...
Associative plasticity and afferent regulation of corticospinal excitability in uninjured individuals and after incomplete spinal cord injuryDownload
Cortical representations are plastic and are allocated based on the proportional use or disuse of a pathway. A steady stream of sensory input maintains the integrity of cortical networks; while in contrast, alterations in afferent activation promote sensorimotor reorganization. After an...
Development of Surrogate Spinal Cords for the Evaluation of Electrode Arrays Used in Intraspinal ImplantsDownload
A surrogate spinal cord was developed to test the mechanical stability of electrode arrays for intraspinal implants. The mechanical and surface properties of candidate materials were tested. The elastic modulus was characterized using dynamic mechanical analysis. Forces required to indent the...
Functional electrical stimulation (FES) is a rehabilitative technology that can be used to improve walking in individuals with mobility impairments due to neurologic injury or disease. Feedback is essential for efficient FES-assisted walking. The overall goal of my project was to investigate...
Investigation of intermittent electrical stimulation as a potential prophylaxis against the formation of deep pressure ulcers after spinal cord injuryDownload
Deep tissue injury (DTI) is a severe form of pressure ulcers resulting from ischemia and mechanical damage due to unrelieved pressure. Despite many preventative methods, none so far has significantly reduced the incidence of DTI. The use of a novel method of pressure ulcer prevention,...
MODELING INCOMPLETE CERVICAL SPINAL CORD INJURY IN RATS TO EXPLORE MECHANISMS OF REHABILITATIVE TRAININGDownload
Although limited functional recovery is observed following spinal cord injury (SCI), the most successful approach to promote recovery to date has been rehabilitative training. However, the effects of training are not stunning. With a thorough understanding of the intracellular mechanisms involved...
Walking is a locomotor task that integrates information from all over the nervous system. The lumbosacral spinal cord houses neural networks that contribute to locomotion. These networks dominate locomotor activity during development and may provide suitable targets for restoring function after...
Spinal cord injury is a devastating neurological disorder partially characterized by a loss of motor function below the lesion. The dramatic loss of activity results in muscle atrophy and slow-to-fast transformation of contractile elements, producing smaller, weaker and more fatiguable muscles....
Neuronal Mechanisms of Hyperexcitability in Individuals with Spasticity after Spinal Cord Injury and Individuals with BruxismDownload
Motoneuron hyperexcitability is a characteristic of several different motor disorders. We examined neuronal mechanisms of hyperexcitability in two of these disorders: spasticity after spinal cord injury (SCI) and bruxism. Involuntary muscle spasms after SCI occur as a result of uncontrolled...