Usage
  • 35 views
  • 209 downloads

Acid Labile Surfactants Containing Ketal-Linkage in Micellar Electrokinetic Chromatography and Electrospray Ionization Mass Spectrometry

  • Author / Creator
    Stanley, Bob
  • The combination of micellar electrokinetic chromatography (MEKC) with electrospray ionization mass spectrometry (ESI-MS) would yield a very powerful analytical technique. However, hyphenating both techniques is not easy. Sodium 4-[(2-methyl-2-undecyl-1,3-dioxolan-4-yl) methoxy]-1-propane sulfonate (ALS) and sodium 2,2-Bis(hexyloxy)propyl sulphate (OALS) are possible solutions to link MEKC with ESI-MS. They are surfactants that are hydrolyzable under acidic condition. Their hydrolysis products are compatible with ESI-MS. They can be utilized as pseudostationary phases to perform a separation and then acid-hydrolyzed before being introduced into the ESI-MS. Both surfactants are compared with sodium dodecyl sulphate (SDS). ALS and OALS offer different selectivity than SDS. In term of mobility, ALS has a slower mobility than SDS. OALS has a greater mobility than SDS. ALS contains a cyclic ketal while OALS contains an acyclic ketal. OALS hydrolyzes much faster than ALS. The hydrolysis can be slowed down by lowering the temperature and vice versa.

  • Subjects / Keywords
  • Graduation date
    2012-11
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3V98031K
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Chemistry
  • Specialization
    • Analytical
  • Supervisor / co-supervisor and their department(s)
    • Lucy, Charles (Chemistry)
  • Examining committee members and their departments
    • Li, Liang (Chemistry)
    • Amirfazli, Alidad (Mechanical Engineering)